Yung-Cheng Jay Chiang

Hi! 你好! Bonjour! Guten Tag! I am Jay, a third-year master’s student at EPFL, Switzerland, specializing in Life Sciences Engineering.

Currently, I am working on my master’s thesis with Prof. Bernd Bodenmiller on the development of a highly-multplexed, ultra-fast optical pooled CRISPR screening workflow by leveraging mass spectrometry imaging.

On one hand, I am applying molecular engineering tools to design detectable barcodes for functional genomic screens. On the other hand, I am also optimizing data acquisition and analysis pipelines to enable high-resolution genotype/phenotype profiling.

Research Interests

I appreciate new methodologies that enable new scientific discoveries. In an interdisciplinary field like biological sciences, in which targets of interest showcase a high level of complexity and dynamical properties, precise measurement and manuipulation tools are crucial prerequisites to theorization. Throughout my academic training, I have thus been continuing asking the same question: “How can we capture, probe, and recapitulate biological complexity with great spatiotemporal resolution?”. To answer this question, I worked on the following topics (in a timely order)

Organoid Culture and Engineering, with a focus on the optimization of high-throughput sphere formation and the development of novel organoid culture systems.
Optical Microscopy and Bioimaging Analysis, particularly in the application of real-time biosensing and image-based single-cell analysis.
Molecular Engineering, with a emphasis on the development of synthetic circuits on the proteomic level.

In the future, I may also want to explore topics in immunology, neuroscience, and the latest tools (i.e., fundamentional models in omics, optogenetics, assembloids…). I strongly believe that these technologies would be the key players and complement each other, facilitating discovery-driven sciences with scalable biomedical impacts.

Check my project to see more research details.

Publications

Ansaryan, S., Chiang, Y.-C., Liu, Y.-C., Reichenbach, P., Irving, M., & Altug, H. (n.d.). Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single-Cell Secretory and Intracellular Dynamics. Advanced Science, n/a(n/a), 2415808. https://doi.org/10.1002/advs.202415808

Experiences

2024.11 - Present: Master Thesis Student at Prof. Bernd Bodenmiller’s Lab, ETH Zurich/University of Zurich, Switzerland
2024.04 - 2024.11: Research Intern at Roche pRED Immunology, Switzerland
2022.10 - 2024.04: Research Assistant at Prof. Hatice Altug’s Lab, EPFL, Switzerland
2023.09 - 2023.12: Teaching Assistant in Biomedical Optics, EPFL, Switzerland
2020.09 - 2022.07: Research Assistant at Prof. Yanyi Huang’s Lab, Peking University, China
2017.10 - 2018.06: Research Trainee at Prof. Yung-Jen Chuang’s Lab, National Tsinghua University, Taiwan

Education

2022.09 - Present: Master of Science in Life Sciences Engineering, École polytechnique fédérale de Lausanne (EPFL), Switzerland
2018.09 - 2022.07: Bachelor of Science in Integrated Sciences, Peking University (PKU), China
2016.09 - 2018.06: High School Diploma, High Achievement in Science, Taichung First Senior High School (TCFSH), Taiwan